2008-09-24: LD data for HapMap phase3 available for download

Linkage Disequilibrium data for autosomes genotyped in HapMap phase 3 (NCBI build 36, dbSNP b126) is now available for download.

2008-09-17: HapMap Phase 3 data available on genome browser

Genotypes and frequency data for HapMap phase 3 (NCBI build 36, dbSNP b126) are now available for browsing. This dataset does not include genotype data from phase 1 and 2.

2008-09-17: HapMap Phase 3 Tutorial
58th ASHG Annual Meeting, Philadelphia, Pennsylvania, USA

Tuesday, 11th November 2008, 5.00-6.30 PM
Philadelphia Convention Center, Room 105B

The HapMap Data Coordination Center is pleased to present a 1.5-hour tutorial during the 58th Annual Meeting of the American Society of Human Genetics. The tutorial will provide an overview of the project, a comprehensive tour and live demo of the HapMap website featuring HapMap Phase 3 Data, and Q&A session. Seating is limited to 30 participants. For pre-registration or additional information, please contact help@hapmap.org.

2008-07-01: HapMap Phase 3 first draft release

Genotypes and frequency data for phase 3 (NCBI build 36, dbSNP b126) of the HapMap are available for bulk download. These datasets will subsequently be made available in the HapMap genome browser and HapMart utility.

2008-06-30: Phased haplotypes for JPT+CHB available (NCBI build 36)

2008-06-24: HapMap Tutorial: Working with the HapMap Website
International Congress of Human Genetics, Berlin, Germany

International Congress Centrum, Salon 21
Saturday, 12th July 2008, 12.30-1.30 PM.

The HapMap Data Coordination Center is pleased to present a one-hour tutorial during the XX International Congress of Genetics. The tutorial will provide an overview of the project, a comprehensive tour and live demo of the HapMap website featuring HapMap Phase 3 Data, and Q&A session. Seating is limited to 30 participants.

2008-06-11: Linkage Disequilibrium data for rel #23a

Three LD properties [LOD score, D' and r2] were calculated from genotype data in rel #23a, and are now available for download.

2008-05-27: HapMap Phase 3 data - preliminary release

The preliminary release of HapMap Phase 3, containing genotype and pedigree information for 11 populations (including individuals in the original 4 from earlier phases of the project), is now available for download.

This data has not yet been thoroughly quality control checked. More information can be found in the README file that accompanies the data file.

2008-04-14: HapMap Rel #23a available in HapMart

Genotypes, frequency and assay data for SNPs for release #23a (NCBI build 36, dbSNP b126) are now available for analysis through the HapMart utility. New platform and genotyping center implemented.

2008-04-01: HapMap Public Release #23a available

Genotypes and frequency data for this release are now available for bulk download and browsing. Positional errors identified in previous release #23 have now been corrected. Please refer to the release notes for additional information.

2008-03-25: Genetic map for CEU and YRI available

Genome-wide recombination rates for CEU and YRI are now available for bulk download. A new genetic map including JPT+CHB data is expected to be released later in the year.

2008-03-06: Phased haplotypes for JPT+CHB under scrutiny

Phased haplotypes for JPT+CHB have been removed from public view. An announcement will be made when this has been sorted out.

2008-02-21: Incorrect position for merged SNPs in rel #23

The position of ~24,500 SNPs was inadvertently entered incorrectly in HapMap release #23 bulk files (genotypes and frequencies). A complete list of affected SNPs can be found here. Errors are being corrected and new genotypes and frequency files will be made available shortly under HapMap release #23a.

2008-02-06: HapMap inferred genotypes (rel#22)

Genotypes were inferred for 73 CEPH children using the method of Burdick et al. (Nat Genet 38:1002-4) and based on the genotypes of 60 CEPH individuals in the same families. Data and list of CEPH samples are available here.

2008-01-31: HapMap Public Release #23

Genotypes and frequency data for this release are now available for bulk download. These datasets include SNPs in the Affymetrix 6.0 array, as well as SNPs excluded from release #22 which have now been merged into new rs# identifiers in dbSNP 126 (NCBI b36). Lists of merged SNPs may be found here. Please refer to the release notes for additional information.

2007-12-20: Official release of HapMap Phased Haplotypes in NCBI b36 coordinates

2007-12-12: Genotype imputation using MACH1 software now available on HapMap Genome Browser

Impute genotypes for all HapMap SNPs in a given region by providing a subset of genotypes on HapMap SNPs. Browse a region of interest, upload your own data (Impute Data plugin), and modify the visualization of user-provided and imputed SNPs. MACH1 imputation available for release #21 (NCBI build 35).

2007-12-12: Assembly errors in rel#22 phased files

2007-10-17: HapMap Phase II article published

2007-08-13: Phased haplotypes in NCBI b36 coordinates

2007-07-17: HapMap Tutorial: Working with the HapMap Website
ASHG Annual Meeting, San Diego, California, USA
October 25th, 2007 at 18:30 PST

San Diego Marriott Hotel and Marina, Rancho Las Palmas, 4th Level, South Tower

The HapMap Data Coordination Center is pleased to present a one-hour tutorial during the 2007 ASHG Annual Meeting.The tutorial will provide an overview of the International HapMap Project, a comprehensive tour of the HapMap website, a live demo of new tools and resources, and Q&A session.

2007-06-04: Predicted OMIM associations available in GBrowse

The OMIM associations track presents data from the MutaGeneSys database, which links genotype data from HapMap and whole genome association studies with the known disease variants reported by the OMIM database. Example of a region with multiple OMIM associations: Chr1:194923128..194933127

2007-05-29: Newly phased haplotypes available for non-par segment of ChrX

Genotyping data for phase I+II (rel #21) was rephased for the non-pseudoautosomal (non-par) region of chromosome X. Data is currently available for bulk download.

2006-06-14: Wellcome Trust Course: Working with the HapMap
Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
November 16-19th, 2007

The Wellcome Trust Course: Working with the HapMap will be held on November 16-19th, 2007 at the Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. The deadline for application is 10th August 2007. Further information can be found at: http://www.wellcome.ac.uk/doc_WTX038039.html with details of how to apply.

2007-04-20: HapMap Rel #22 available in GBrowse and HapMart

Genotypes, frequency and assay data for SNPs remapped to NCBI build 36 (dbSNP b126) coordinates are now available for graphic display and through the HapMart utility.

Note: Phased genotypes for HapMap data in NCBI build 36 coordinates are being generated and will be made available at a future date.

2007-04-12: Perlegen amplicon mapping data available

Perlegen amplicon mapping data is available for bulk download.

2007-03-02: HapMap Public Release #22

Genotypes and frequency data for SNPs remapped to NCBI build 36 (dbSNP b126) coordinates are now available for bulk download. These datasets will subsequently be made available in the HapMap genome browser and HapMart utility.

As detailed in the release notes, a number of SNPs were excluded from this release due to mapping inconsistencies in Build 35 relative to Build 36. Lists of excluded SNPs according to various criteria may be found here. Please refer to the README file for exclusion criteria and additional information.

2007-02-11: Discrepancies found in phased haplotypes for non-par segment of ChrX

Substantial discrepancies between genotyping data and phased haplotypes were identified for the non-pseudoautosomal (non-par) region of chromosome X. These inconsistencies appear to largely involve hemizygous males of all population panels. Caution is advised when using phased data for the region between SNPs rs5939319 and rs557132 until further notice.

2007-01-17: Reactome links updated

Links to the Reactome pathway database from the HapMap genome browser have been updated and improved. Click here for an example.

2007-01-11: HapMap Public Release #21a

Genotype frequencies and assays for phase I and phase II of the HapMap project are now available for bulk download and browsing.

This release contains all processed data from the HapMap project, and includes all data from phases I+II of the project. This release also contains genotypes from the Illumina Infinium 100k and 300k genotyping arrays, Affymetrix nsSNPs, and SNPs typed for a high-resolution map (De Bakker et al. 2006) of the extended MHC locus.

New features in this release include Segmental Duplications and Copy Number Variation (CNV). Segmental Duplications correspond to High-Depth Celera Reads (She et al. 2004; Bailey et al. 2001 & 2002). Structural Variation datasets include:

CNV regions determined in HapMap samples (Redon et al. 2006)

CNV datasets (Iafrate et al. 2004, Sebat et al. 2004, Sharp et al. 2005, Tuzun et al. 2005)

Deletions (Hinds et al. 2006, Conrad et al. 2006; McCarroll et al. 2006)

2006-11-30: Wellcome Trust Course: Working with the HapMap
Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
April 2nd - April 5th, 2007

The Wellcome Trust Course: Working with the HapMap will be held on April 2nd - April 5th, 2007 at the Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. The deadline for application is 10th January 2007. Further information can be found at: http://www.wellcome.ac.uk/doc_WTX030611.html with details of how to apply.

This 4-day residential course will provide a comprehensive overview of the International HapMap Project, and will include practical experience of working with the HapMap data to map phenotypic traits to locations in the human genome. Theoretical lectures will be combined with hands-on practical sessions and introduction to relevant databases and tools.

Topics include: Introduction to the HapMap, Introduction to Association Studies, Data collection and repositories, Genetic variation and selection, Tools and resources, Association analysis, and Case studies.

Course instructors and speakers include: Paul de Bakker (MIT), Manolis Dermitzakis (Sanger Institute), Mike Feolo (NIH/NCBI), Jonathan Marchini (Oxford University), Gil McVean (Oxford University), Steve Sherry (NIH/NCBI)), Albert Vernon Smith (CSHL), Barbara Stranger (Sanger Institute), Eleftheria Zeggini (Wellcome Trust Center for Human Genetics), Lon Cardon (Wellcome Trust Center for Human Genetics), Panos Deloukas (Sanger Institute), John Todd (Cambridge University).

2006-11-14: Phased haplotypes now available in HapMart
Phased haplotypes output now available for the CEU, YRI and the combined Asian panel (JPT+CHB) datasets.

2006-10-09:New Features and Datasets Available
The website of the International Haplotype Map Project has a number of new features and datasets which are being released today.

New Features at hapmap.org:
• When browsing data from release 21, there is now a new "region" view. This is intermediate between the detailed view, and the chromosomal overview. The region view displays 200kb, giving a broader overview of the chromosomal region, while greater details can still be seen concurrently in the detailed view.
• There are new tracks in the browser which display expected LD values (r^2) within windows along the chromosome
• Recombination rates and hotspots data are now available for release 21.
• There is a new plugin which downloads phased genotypes for the region being browsed. Under the configuration options, one can chose the panel to download, as well as additional options for filtering the SNPs. To download, select "Download Phased Haplotype Data" under "Reports & Analysis".

New datasets:

• The raw data (CEL files) from the Affymetrix GeneChip 500k Mapping Arrays on the HapMap samples are available for download.
• Genotypes inferred using the method of Burdick et al. (Nat Genet 38:1002-4). Starting with the genotype of 60 CEPH individuals, the methodology infers the genotypes for 78 CEPH children in the same families.

2006-07-20: HapMap Public Release #21
Genotypes, frequencies and assays for phase I and phase II of the HapMap project are now available for bulk download. The files contain all phase I and II data combined.

In addition to expressing the genotypes relative to the dbSNP rs sequence, this release contains a set of files expressing genotypes relative to the forward strand of NCBI build 35. The genotypes are identical, and are complement for SNPs where the rs sequence maps to the reverse strand of the genome build.

The phased genotypes are expressed relative to the forward strand of build 35, so the displayed alleles will read as a haplotype across a single strand along the chromosome.

2006-03-30: Wellcome Trust Course: Working with the HapMap
Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Jul 31st - Aug 2nd, 2006

The Wellcome Trust Course: Working with the HapMap will be held on July 31st - August 2nd, 2006 at the Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. The deadline for application is 14th April 2006. Further information can be found at: http://www.wellcome.ac.uk/doc_wtx030611.html and details of how to apply.

This 3-day residential course will provide a comprehensive overview of the International HapMap Project, and will include practical experience of working with the HapMap data to map phenotypic traits to locations in ethe human genome. Theoretical lectures will be combined with hands-on practical sessions and introduction to relevant databases and tools.

Course instructors: Goncalo Abecasis (University of Michigan), Paul de Bakker (MIT), Andy Clark (Cornell University), Panos Deloukas (Sanger Institute), Jonathan Marchini (Oxford University), Albert Vernon Smith (CSHL), Ellen Wright Clayton (Vanderbilt University), Gil McVean (Oxford University), Steve Sherry (NIH/NCBI)), Mike Feolo (NIH/NCBI).

2006-01-24: HapMap Public Release #20
The HapMap project is happy to make a new release of the dataset. This release contains a remapping of the previous release (#19) on NCBI Build 35 coordinates. As detailed in the release notes, 30,828 SNPs were excluded from this release due to mapping inconsistencies in Build 34 relative to mappings in Build 35.
The data are available for bulk download and for graphical browsing. At the moment, the release does not include phased haplotypes, as that data still needs to be calculated.

2006-02-24: Beyond HapMap 3rd Annual International HapMap Project Community Analysis Meeting
The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
May 8-10, 2006

The deadline for submitting an abstract is Friday, March 31, 2006.
The deadline for registration is Friday, April 14, 2006.

Lecture seating is limited; therefore, early registration is encouraged. Capacity may be met prior to the April 14 deadline. Complete instructions for abstract submission and registration, and further details of the conference, can be found at conference web site.

2005年10月24日：HapMap数据第19次公布
HapMap项目第一期和第二期的基因分型、频率和实验设计等数据现在可以下载。这批数据将所有第一期和第二期数据混合在一起。

2005年9月28日：HapMap第18次数据公布
2、6、11、14、15和21号染色体最新的基因分型、频率和实验设计等数据现在可以 下载。请注意这表示CEU和YRI人群中这些染色体的第二期数据已经完全。这批数据将所有第一期和第二期数据混合在一起。本次数据公布的概要如下：

2005年9月21日：HapMap指导会议——美国人类遗传学协会（American Society of Human Genetics，ASHG）2005年年会

Salt Palace Convention Center，Ballroom ABCD，周四，10月27日，下午6点30分至8点30分

Wellcome Trust和NIH/NHGRI将就有效使用HapMap数据提供2小时的指导，包括HapMap介绍（Dr. Aravinda Chakravarti，Johns Hopkins University），在关联研究中使用HapMap数据、tagSNP的选择和选择SNP使用芯片进行研究（Dr. Mark Daly，Broad Institute），HapMap网页使用指导（Dr. Lincoln Stein，CSHL），其他的演讲者包括Dr. Toshihiro Tanaka（RIKEN），Dr. Michael Boehnke（University of Michigan）和Dr. Augustine Kong（deCODE）等。

注册人数限制在1000人，注册截至日期为2005年10月14日，会议没有额外的费用，但是参与者首先必须先注册参与ASHG会议。

更多的信息以及注册，请访问，http://www.capconcorp.com/hapmaptutorial.

2005年9月19日：HapMap使用者调查
请花费片刻时间来参加 HapMap使用者调查，这将帮助我们不断改善，以满足您的需求。

2005年8月17日：首次HapMap第二阶段数据发布
首批发布的HapMap第二阶段数据现在可进行 批量下载。本次发布的数据来自第二阶段最初在2号染色体短臂上的引导性工作。这批数据对先前发布的第一阶段数据（16c.1）是一个补充，将这些数据文件联合起来就能得到全部数据。这批数据包括对600,180个新的SNP位点的基因分型（共计54,016,200反应）。

2005年6月21日：HapMap数据公布 #16c.1.
这是最终冻结的第一阶段数据，将用于随后的HapMap文章（详见数据发布前的冻结 ）。这次公布的数据中，将把中国北京汉族人样品的简称改作CHB（详见HapMap出版和介绍中关于项目取样群体的指导方针）。基因分型的SNP位点的总结如下：

2005年2月8日： HapMap新闻 2004年第一卷
这是Coriell医学研究所出版的系列通讯的第一卷，旨在告知社区成员他们的样本如何被使用。该通讯中的所有文章都将以参与样本捐赠的社区的语言来获取。

2005年2月7日： 国际HapMap协作组扩大制图规模
在获得额外的三百三十万美元公众-私人资金后，国际HapMap协作组宣布创造一张比原计划更加强大的人类遗传变异图。该图将加速发现与如哮喘、癌症、糖尿病和心脏病等常见疾病相关的基因。

2005年5月27日：即将到来的HapMap数据发布
随着接近对第一期基因分型数据检查的完成，某些SNP位点被认为是存在问题的，这使得它们的基因分型结果的质量过低或者错误。新版的数据对这些问题进行了修正。这些数据正在准备当中，预计将在下周发布。在这期间，对这些数据的描叙以及有问题的SNP位点的列表将在看到 。

2005年3月1日：第16次数据公布
这是本项目第一期工作的数据，是本项目的一个里程碑，包括在所有被研究人群中对共有SNP进行5kb密度的分型。数据可从批量下载或图形浏览获得。SNP分型结果的总结如下：

2005年02月18日： 第15次数据公布
有关中国汉族人群、日本人群和约鲁巴人群样本的额外信息，请从点击此处获得。基因分型数据可批量下载。已分型SNP的情况可看。

2004年12月10日：获取HapMap基因分型数据不再需要签署clickwrap协议书。使用者请查看数据使用指导中的相关条款，以确保免费而又无障碍的获得数据。同时可阅读旧的协议书以作参考。

2004年12月10日： HapMap会议：基因组研究和HapMap 英国牛津大学： 2005年3月15日-18日

到2005年3月，HapMap项目将完成第一阶段（在270个个体中对60万个常见的SNP进行基因分型），并开始第二阶段（在相同的样品中对225万额外的SNP进行基因分型）的工作。但是，在遗传研究中如何更好的利用这些信息，仍然是未解决的问题。此次会议由牛津大学统计系主持，中心议题是在人类疾病研究、群体遗传和进化分析等基因组研究中使用HapMap资源。

不论是直接参与HapMap项目，或是分析各种数据，或是关注疾病研究，“基因组研究和HapMap”将为这些不同的研究机构提供重要的机会，使它们能够聚在一起，明确并讨论与使用HapMap数据相关的问题。会议还将提供对HapMap项目的进展和结果的最新的评价。HapMap项目以外的特邀报告人有Andy Clarke，David Clayton，Mark McCarthy，Jonathan Pritchard，Matthew Stephens和Simon Tavaré。2004年春季成功的召开了一次会议，100多位与会者对与HapMap项目相关的方法学和数据分析感兴趣，此次会议有望延续上次会议的成功。

我们邀请您参与并注册此次会议，并希望您能为海报或简介提交摘要。
摘要提交的截止日期为2005年1月28日。
注册/房间预订的截止日期为2005年2月25日。
有关提交摘要、注册会议的细节指导，以及此次会议的细节内容，请参考本次会议的网站 http:/www.hapmap.org/oxford_conference/default.html。

2004年12月10日： 第14次数据公布
有关中国汉族人群、日本人群和约鲁巴人群样本的额外信息，请从点击此处获得。基因分型数据可批量下载。已分型SNP的情况可看。

2004年11月23日：第13次HapMap公共数据发布，现在可以获得所有三个HapMap取样人群的数据。
有关中国汉族人群、日本人群和约鲁巴人群样本的额外信息，请从点击此处获得。基因分型数据可批量下载。已分型SNP的情况可看。

2004年10月12日：新通用基因组浏览器的特点
当使用浏览器时，可对连锁不平衡（LD），杂合度和SNP覆盖度等信息进行追踪。能使用三种方法来进行LD分析：LOD值（LOD score），D''和 R Square。LD数据可通过下载获得。能够打开或关闭对浏览区域的总览（Overview）。SNP分型结果上以不同字体显现等位基因频率信息。

2004年10月12日：获取HapMap计划所用的实验方案。包括HapMap计划中的实验设计、分型结果、数据递交程序和质量评价/质量控制等内容。

2004年10月12日： 第12次数据公布
共发布752,208个SNP位点的基因分型、基因型频率和实验数据（其中共有67,698,720个基因分型数据），可通过下载和 图形浏览获得这些数据。

2004年8月26日：发布与HapMap计划相关的新信息。
现在可获得什么是HapMap？单体型的起源、对人类的益处、取样群体、伦理学问题、数据发布政策等方面对的内容。

2004年09月02日： 第11次数据公布
共发布693,255个SNP位点的基因分型、基因型频率和实验数据（其中共有62,393,760个基因分型数据），可通过下载和 图形浏览获得这些数据。

2004年9月28日：网络维护计划
定于美国东部时间（EST）10月2日下午10点至次日凌晨6点，对位于冷泉港实验室的网络系统进行维护，届时HapMap主页及其他相关网页将暂时关闭，我们对此表示歉意。

2004年08月16日： 第10次数据公布
共发布661,094个SNP位点的基因分型、基因型频率和实验数据（其中共有59,498,460个基因分型数据），可通过下载和 图形浏览获得这些数据。

2004年07月20日： 第9次数据公布
共发布639,110个SNP位点的基因分型、基因型频率和实验数据（其中共有57,519,900个基因分型数据），可通过下载和 图形浏览获得这些数据。

2004年06月15日： 第8次数据公布
共发布614,030个SNP位点的基因分型、基因型频率和实验数据（其中共有55,262,700个基因分型数据），可通过下载和 图形浏览获得这些数据。

2004年5月27日： “国际HapMap项目中科学与伦理的结合”一文将于2004年6月在 Nature Reviews Genetics上发表

2004年05月04日： 第7次数据公布
共发布557,083个SNP位点的基因分型、基因型频率和实验数据（其中共有50,137,470个基因分型数据），可通过下载和 图形浏览获得这些数据。

2004年04月09日： 第6次数据公布
共发布462,670个SNP位点的基因分型、基因型频率和实验数据（其中共有41,640,300个基因分型数据），可通过下载和 图形浏览获得这些数据。

2004年03月05日： 第5次数据公布
共发布369,784个SNP位点的基因分型、基因型频率和实验数据（其中共有33,280,560个基因分型数据），可通过下载和 图形浏览获得这些数据。

2004年02月06日： 第4次数据公布
共发布324,613个SNP位点的基因分型、基因型频率和实验数据（其中共有29,215,170个基因分型数据），可通过下载和 图形浏览获得这些数据。

2004年01月07日： 第3次数据公布
共发布274,571个SNP位点的基因分型、基因型频率和实验数据（其中共有24, 000,000个基因分型数据），可通过下载和 图形浏览获得这些数据。